Nasa has flown 113 manned flights.
2 manned flights have resulted in the deaths of the crew.
There have been at least 39 seperate people in space via NASA. (I'm still counting.)
Nasa has never lost a person in space.
Columbia is the first (and hopefully only) loss of people on a landing.
Apollo 1 is the only loss of people during testing.
Challenger is the only loss of people on a takeoff.
There is always about a two minute contact black out between a shuttle and ground control during re-entry.